Based on one of the most critically acclaimed comics of all time. A mysterious plague has wiped out all men on the planet, and women are left to pick up the pieces of society. The only surviving man is Yorick, an amateur escape artist who is the key to the continual survival of the human race. Special Agent 355 is tasked to protect his life at all costs. Luckily, she's really good at her job.

An aerialist rehearsing for a rock tour battles age, injury, and a young director scheming to end her career, while a mysterious reporter digs into the ghosts of her past.